Table 3.
Odds ratios (ORs) with 95% CIs for women with premature ovarian insufficiency (POI, n = 3972) having an autoimmune disease prior to POI diagnosis,a as compared to reference cohort (n = 15 708).
| Autoimmune diseases | OR | 95% CI |
|---|---|---|
| Endocrine diseases | ||
| Hyperthyroidism | 1.9 | 1.2, 3.1 |
| Polyglandular autoimmune diseases (APECED, Schmidt syndrome, unspecified) | 25.8 | 9.0, 74.1 |
| Diabetes type I | 1.1 | 0.7, 1.9 |
| Addison’s disease | 22.9 | 7.9, 66.1 |
| Inflammatory diseases | ||
| Rheumatoid arthritis | 2.3 | 1.7, 3.2 |
| Ankylosing spondylitis | 1.1 | 0.5, 2.3 |
| Inflammatory bowel diseases (Crohn’s disease and colitis ulcerosa) | 2.2 | 1.5, 3.3 |
| Sarcoidosis | 2.3 | 1.2, 4.5 |
| Vasculitis | 10.2 | 4.3, 24.5 |
| Systemic lupus erythematosus | 6.3 | 4.2, 20.3 |
a
Prior to the index date, i.e. the date when reimbursement for hormone replacement therapy (HRT) was granted for the case with POI.