Figure 2.

Landscape of SYK gain of function genomic alterations in cancers. (A, B) Schematic of 2 cases of ITK-SYK rearrangements identified via review of FoundationCORE®, The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Oncology Research Information Exchange Network (ORIEN). (A) A T-cell neoplasm involving exons 1-13 of ITK and (B) a myeloproliferative neoplasm involving exons 1-5 of ITK. Both rearrangements retain the tyrosine kinase domain of SYK. (C) Lollipop diagram demonstrating unique SYK gain of function single nucleotide variants (SNV) in exons 8-14 identified through a review of clinical-genomic database from FoundationCORE®, ICGC, TCGA, and ORIEN. (D) Frequency of gain-of-function SNV (illustrated in (C)) by cancer type.