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. 2024 Jul 24;84(21):3574–3588. doi: 10.1158/0008-5472.CAN-23-3074

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©2024 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 1. — FOXP4 is overexpressed in gastric cancer and is correlated with poor survival. A, Clinical cases with genetic or mRNA alterations in FOXPs in TCGA cohort. The genetic and mRNA alterations in FOXP1 to FOXP4 account for 4.9%, 5.2%, 6.9%, and 16.2% of gastric cancer cases, respectively. B, Copy number gain or amplification of FOXP4 in primary gastric cancer samples (n = 2) was detected by FISH analysis. C and D,FOXP4 mRNA levels in nonpaired and paired samples from TCGA-STAD dataset. E, IHC staining of the expression and cellular localization of FOXP4 in cancer cells and adjacent normal tissues (n = 3). F and G, Western blot analysis (n = 2) of FOXP4 protein expression in paired gastric cancer tissues and cell lines. N, adjacent nontumor; T, tumor. H and I, High FOXP4 expression was associated with poor prognosis in both Hong Kong and Beijing cohorts.