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Overall schematic presentation of the YAP1–FOXP4–SOX12 axis in gastric cancer. YAP1 directly regulates FOXP4 expression via binding its promoter. FOXP4 exerts oncogenic properties by upregulating SOX12. As a novel therapeutic target, depleting FOXP4 suppresses cancer cell stemness, reverses drug resistance, and reduces peritoneal metastasis. Small molecule targeting FOXP4 quenches YAP1-driven gastric tumor progression and enhances the 5-FU efficacy. (Created with BioRender.com.)
