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. 2024 Nov 4;4(11):2868–2876. doi: 10.1158/2767-9764.CRC-24-0301

Table 5.

Multivariable-adjusted analyses of sex-specific quartiles of R-SOD activities and cancer risk

Cohort Comparison Multivariable model 1a Multivariable model 2b
HRc (95% CI) P HRc (95% CI) P
Totald Q2 vs. Q1 1.10 (0.70–1.76) 0.661 1.10 (0.69–1.75) 0.686
Q3 vs. Q1 1.21 (0.76–1.92) 0.423 1.20 (0.75–1.91) 0.444
Q4 vs. Q1 1.63 (1.04–2.54) 0.034 1.61 (1.03–2.52) 0.037
Women Q2 vs. Q1 1.24 (0.57–2.71) 0.583 1.23 (0.57–2.69) 0.597
Q3 vs. Q1 1.33 (0.63–2.83) 0.458 1.33 (0.63–2.83) 0.457
Q4 vs. Q1 1.48 (0.71–3.10) 0.299 1.46 (0.70–3.05) 0.320
Men Q2 vs. Q1 1.67 (0.87–3.20) 0.122 1.68 (0.88–3.21) 0.119
Q3 vs. Q1 1.62 (0.84–3.12) 0.149 1.63 (0.85–3.15) 0.142
Q4 vs. Q1 2.49 (1.35–4.61) 0.004 2.49 (1.35–4.59) 0.003
a

Multivariable model 1 includes age, current smoking habit, alcohol use, physical activities, body mass index, SBP, and serum total cholesterol as covariates.

b

Multivariable model 2 includes age, current smoking habit, alcohol use, physical activities, body mass index, plasma IRI, and non–HDL-C as covariates.

c

Baseline R-SOD activities in the total cohort, women, and men populations were separately divided into quartiles based on sex, and HRs of each quartile population were estimated with the use of the Cox proportional hazards model using quartile 1 as a reference group.

d

For the total cohort, sex was also used as a covariate in addition to the other variables.