Table 6.
Multivariable-adjusted analyses of sex-specific quartiles of R-SOD activities and cancer risk, after excluding the events within 5 years from the baseline survey
| Cohort | Comparison | Multivariable model 1a | Multivariable model 2b | ||
|---|---|---|---|---|---|
| HRc (95% CI) | P | HRc (95% CI) | P | ||
| Totald | Q2 vs. Q1 | 1.10 (0.70–1.76) | 0.661 | 1.34 (0.75–2.40) | 0.328 |
| Q3 vs. Q1 | 1.21 (0.76–1.92) | 0.423 | 1.42 (0.78–2.58) | 0.246 | |
| Q4 vs. Q1 | 1.78 (1.00–3.18) | 0.052 | 1.78 (1.00–3.17) | 0.052 | |
| Women | Q2 vs. Q1 | 1.67 (0.69–4.07) | 0.257 | 1.67 (0.69–4.05) | 0.260 |
| Q3 vs. Q1 | 1.17 (0.46–2.99) | 0.741 | 1.17 (0.46–2.98) | 0.747 | |
| Q4 vs. Q1 | 1.03 (0.39–2.70) | 0.956 | 1.01 (0.39–2.65) | 0.983 | |
| Men | Q2 vs. Q1 | 2.68 (0.87–3.20) | 0.042 | 2.74 (1.06–7.08) | 0.037 |
| Q3 vs. Q1 | 2.76 (0.84–3.12) | 0.038 | 2.87 (1.10–7.46) | 0.031 | |
| Q4 vs. Q1 | 4.56 (1.84–11.26) | 0.001 | 4.64 (1.88–11.45) | 0.001 | |
Multivariable model 1 includes age, current smoking habit, alcohol use, physical activities, body mass index, SBP, and serum total cholesterol as covariates.
Multivariable model 2 includes age, current smoking habit, alcohol use, physical activities, body mass index, plasma IRI, and non–HDL-C as covariates.
Baseline R-SOD activities in the total cohort, women, and men populations were separately divided into quartiles based on sex, and HRs of each quartile population were estimated with the use of the Cox proportional hazards model using quartile 1 as a reference group.
For the total cohort, sex was also used as a covariate in addition to the other variables.