Figure 4.

H4 tail acetylation increases intramolecular contacts. (A) Intramolecular contact map differences for 3Ac and 5Ac MD simulations compared to unAc. Color gradient values refer to the change in the fraction of simulation time each residue pair spent in contact, with positive values indicating increased contact. (B) PRE histograms of signal intensity ratios between paramagnetic and diamagnetic samples for unAc and 5Ac NMR samples. Asterisks mark resonances for which the reported intensity ratios are indistinguishable due to degenerate resonance positions. (C) Difference between the intensity ratios reported in panel B for unAc compared to 5Ac, positive values indicate increased proximity to the probe in the 5Ac NMR sample.