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. 2024 Nov 3;15:20406207241292508. doi: 10.1177/20406207241292508

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© The Author(s), 2024

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Median and arithmetic mean (SD) pre-dose (trough). (a) Serum concentration-time profiles and (b) serum PD (P-selection inhibition)-time profiles for crizanlizumab.

The PD analysis set included all patients who received at least one planned treatment of 5.0 or 7.5 mg/kg and provided at least one corresponding evaluable PK concentration. PD, pharmacokinetic; SD, standard deviation.