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. Author manuscript; available in PMC: 2024 Nov 4.
Published in final edited form as: Int Rev Neurobiol. 2019 Jun 6;145:127–176. doi: 10.1016/bs.irn.2019.05.002

Fig. 1.

Fig. 1

Schematic of mitochondrial fission and fusion dynamics. Mitochondrial bioenergetics are regulated by mitochondrial fission and fusion events. Mitochondrial fusion events retain mitochondrial bioenergetic function, MMP, ATP production, and decrease ROS generation and apoptosis. Conversely, mitochondrial fission leads to mitochondrial depolarization which impairs mitochondrial bioenergetic function and decreases ATP production. Compromised bioenergetics lead to ROS production triggering apoptosis.