Fig. 2.

A dietary switch from a SFA-rich HFD to a MUFA-rich HFD restores nerve function in a murine model of prediabetes and neuropathy. A) Mice fed a SFA-rich HFD develop robust neuropathy phenotypes including a decrease in sensory and motor nerve conduction velocity and a reduction in intraepidermal nerve fiber density. In line with these results, cultured DRG neurons treated with SFAs exhibit a decrease in axonal mitochondrial trafficking and MMP. These mitochondrial changes are associated with apoptosis and a reduction in neuronal ATP level. B) Changing mice from a SFA-rich diet to a MUFA-rich diet restores both nerve and mitochondrial function.