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. 2024 Nov 4;23:297. doi: 10.1186/s12934-024-02557-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 8 — Growth and succinate accumulation of the final mutant. a The logarithmic cell growth graphs of mutant strains (CS405) in the bioreactor. The logarithmic graphs of cell growth were included to show the changes in the growth phase clearly. b Accumulation of succinate during cell growth in the bioreactor. For comparison, the graphs of CS403 and 404 are included