Table 1.
Previously reported cases of salvage surgery for locoregional recurrence following the PACIFIC regimen
| Author | Age/sex | cTNM | Histology | RT-dose (Gy) | Cycles durva | ycTNM | Type of resection | Operating time (mins) | Perioperative complication | Blood loss (ml) | 90-day post-op complications (Clavien-Dindo Gr III-V) | Reintervention < 30 days | pTNM | Margin | Ef | Survival (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dickhoff C. [3] | 53/F | TxN2 | Large | 66 | 25 | T2aN0 | LUL | 159 | – | 50 | – | – | T1cN1 | R0 | ND | 9 (dead) |
| 53/M | T4N0 | Ad | 66 | 19 | T2N0 | RUL | 525 | Tear azygos v./PA | 1100 | – | – | T1bN0 | R0 | ND | 23 (alive) | |
| 64/M | T4N2 | SCC | 60 | 18 | T1cN0 | LLL | 126 | – | 75 | – | – | T2aN0 | R0 | ND | 23 (alive) | |
| 56/M | T4N1 | SCC | 65 | 24 | T1bN2 | RUL | 237 | – | 100 | – | – | T2aN2 | R0 | ND | 19 (alive) | |
| 56/M | T2N2 | SCC | 66 | 25 | T1bN0 | LP | 444 | Tear PA | 4000 | BPF, sepsis, bleeding | Thoracotomy x2 | T2bN0 | R0 | ND | 9 (dead) | |
| 57/M | T3N2 | SCC | 60 | 9 | T2aN0 | RP | 245 | – | 500 | – | – | T2bN1 | R0 | ND | 5 (alive) | |
| 59/F | T2bN3 | Ad | 60 | 4 | T3N0 | LUL (sleeve PA) | 213 | – | 300 | – | – | T3N0 | R1 | ND | 5 (alive) | |
| 73/F | T1N2 | SCC | 60 | 3 | T2aN0 | RUL | 232 | – | 50 | – | – | T3N0 | R0 | ND | 4 (alive) | |
| 67/M | T2N2 | SCC | 60 | 10 | T3N0 | RLL | 298 | – | 150 | – | – | T3N2 | R0 | ND | 2 (alive) | |
| 74/M | T4N0 | SCC | 55 | 12 | T3N0 | RML/RLL | 358 | – | 400 | – | – | T4N0 | R0 | ND | 1 (alive) | |
| Minegishi K. [5] | 61/M | T4N2 | SCC | 66 | 24 | T2aN1 | RUL (PA/Br plasty) | 272 | – | 800 | – | – | T2aN0 | R0 | ND | 10 (alive) |
| Ueno T. [10] | 76/M | T1cN2 | SCC | 60 | ND | T3N0 | RUL | 195 | – | 70 | – | – | T3N0 | R0 | 1b | 18 (alive) |
| 54/M | T3N2 | SCC | 60 | ND | T3N0 | RLL | 513 | – | 1330 | – | – | T1bN0 | R0 | 1b | 4 (alive) | |
| Funaki S. [11] | 70/M | T4N0 | SCC | 60 | 24 | ND | RUL+CW(2-3th) | ND | – | ND | – | – | T1aN0 | R0 | 2 | 24 (alive) |
| Takenaka M. [2] | 72/F | T3N1 | SCC | 66 | ND | T3N0 | RUL+CW(1-4th) | 273 | – | 100 | – | – | T3N0 | R0 | 2 | 17 (alive) |
| Our case | 53/M | T4N3 | Ad | 60 | 24 | T3N0 | LUL+CW(1-4th) | 389 | PA embolism | 270 | – | – | T0N0 | R0 | 3 | 7 (alive) |
M Male, F Female, cTNM Clinical TNM stage of index tumor, pTNM Pathological TNM stage, Large Large cell carcinoma, Ad Adenocarcinoma, SCC Squamous cell carcinoma, RT Radiotherapy, LUL Left upper lobectomy, RUL Right upper lobectomy, LLL Left lower lobectomy, LP Left pneumonectomy, RP Right pneumonectomy, PA Pulmonary artery, Br Bronchus, CW Chest wall resection, ND No data, R0 Radical resection, R1 Microscopic non-radical resection