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. Author manuscript; available in PMC: 2024 Nov 4.
Published in final edited form as: Nat Metab. 2023 May 30;5(5):861–879. doi: 10.1038/s42255-023-00807-w

Fig. 4 ∣. The rs6712203 MONW risk haplotype affects actin remodelling in adipocytes and adipocyte lipid storage capacity.

Fig. 4 ∣

a, Schematic of adipocyte differentiation and LipocyteProfiling of subcutaneous AMSCs derived from TT (n = 7) and CC (n = 6) allele carriers of rs6712203 using LipocyteProfiler43. b,d, Differences in morphological profiles between TT (n = 7) and CC (n = 6) allele carriers at day 14 in subcutaneous (b) and visceral (d) AMSCs (multi-way ANOVA, significance level FDR < 5%). c, Pie chart illustrating non-redundant differential features per channel and class of measurement at day 14 of subcutaneous adipocyte differentiation in rs6712003 homozygous risk carriers compared to non-risk carriers. e,f, Spatial intensity distribution of AGP in the centre of the cytoplasm near the nucleus in subcutaneous adipocytes derived from TT (n = 7), TC (n = 14) and CC (n = 6) carriers of rs6712203 (Cytoplasm_RadialDistribution_ FracAtD_AGP_1of4) (e) andjuxtaposed to the plasma membrane (Cytoplasm_ RadialDistribution_RadialCV_AGP_4of4) (f) throughout differentiation. Multi-way ANOVA; data represent the median ± 95% CI. g,h, Lipid droplet count (Cells_Children_LargeLipidObjects_Count) (g) and intensity of BODIPY stain (Cells_Intensity_IntegratedIntensity_Lipid) (h) throughout differentiation. Multi-way ANOVA; data represent the median ± 95% CI.