Figure 1.

Relative changes in serum and plasma biomarkers in riociguat and placebo groups from baseline to week 14. P-values were generated by exploratory t-test and are for information only. Vertical lines: maximum and minimum values; top of box: 90 percentile; ×: median change; horizontal lines: mean change; bottom of box:10 percentile. ADMA: asymmetric dimethylarginine; cGMP: cyclic guanosine monophosphate; CXCL-4: CXC motif chemokine ligand 4; hsCRP: high-sensitivity CRP; SDMA: symmetric dimethylarginine; sE-selectin: soluble E-selectin; sPECAM-1: soluble platelet endothelial cell adhesion molecule-1