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. 2024 Mar 9;63(11):3124–3134. doi: 10.1093/rheumatology/keae150

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© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Changes in plasma cGMP to week 14 in riociguat arm by week 14 riociguat concentration quartiles. (A) AUC_TAU, (B) C_MAX, and (C) C_TROUGH. AUC_TAU: area under the plasma concentration−time curve. cGMP: cyclic guanosine monophosphate; Chg: change; C_MAX: maximum plasma concentration; C_TROUGH: trough plasma concentration; V8: study visit 8 (week 14). Circles show values for individual patients. Values in parentheses on x-axes are the upper and lower limits of each quartile. Shading of data points is for visualization only. P-values were generated by exploratory t-test and are for information only.