Table 3.

Biomarkers associated with mortality in multivariable analysis combined with gender, age and baseline FVC%

Biomarker	SSc-Total (n = 407) HR (95% CI), P-value	SSc-ILD (n = 252) HR (95% CI), P-value	SSc no-ILD (n = 155) HR (95% CI), P-value
VCAM-1	2.85 (1.86–4.38), P < 0.001	3.11 (1.77–5.46), P < 0.001	3.61 (1.66–7.86), P = 0.001
E-selectin	2.20 (1.51–3.20), P < 0.001	2.29 (1.46–3.61), P < 0.001	2.03 (1.03–4.03), P = 0.042
SP-D	1.94 (1.33–2.83), P = 0.001	1.81 (1.13–2.89), P = 0.014	2.59 (1.24–5.43), P = 0.012
ET-1	1.82 (1.25–2.65), P = 0.002	NS	3.11 (1.51–6.42), P = 0.002
CXCL12	1.75 (1.21–2.54), P = 0.003	1.89 (1.20–2.95), P = 0.006	4.58 (1.98–10.58), P < 0.001
CCL-18	1.66 (1.15–2.39), P = 0.006	NS	2.01 (1.03–3.95), P = 0.042
IL-6	1.65 (1.12–2.42), P = 0.010	NS	2.02 (1.01–4.02), P = 0.046
MMP-3	1.65 (1.12–2.42), P = 0.010	1.79 (1.12–2.86), P = 0.015	NS
MMP-7	1.62 (1.12–2.35), P = 0.010	NS	2.05 (1.03–4.08), P = 0.040
Ca15-3	1.56 (1.08–2.24), P = 0.018	1.71 (1.10–2.65), P = 0.017	NS
MMP-1	1.54 (1.06–2.22), P = 0.023	NS	NS
CXCL4	NS	1.87 (1.20–2.92), P = 0.005	NS

Bold typeface used for statistically significant results (P ≤ 0.05). SSc-ILD, SSc-associated interstitial lung disease; SSc no-ILD, SSc, no interstitial lung disease; NS, not significant; FVC%, forced vital capacity percentage predicted.