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. Author manuscript; available in PMC: 2024 Nov 4.
Published in final edited form as: Nat Aging. 2023 May 25;3(7):846–865. doi: 10.1038/s43587-023-00420-2

Extended Data Fig. 5 |. Inflammation and cytokine production in male senescent Znrf3 cKO adrenal glands is further enhanced at 9-weeks.

Extended Data Fig. 5 |

(a) IPA identifies the most significantly altered canonical pathways in 12- vs 6-week female Znrf3 cKO adrenals. Similar pathways are altered earlier in male Znrf3 cKOs, consistent with the more accelerated phenotype in males. (b) IPA identified the top activated and inhibited cytokines in 9- vs 4-week male Znrf3 cKO adrenals, p < 0.05. (c) GSEA for inflammatory signatures (IL6/JAK/STAT3 signaling, chemokine signaling, the inflammatory response, and the innate immune system) identifies positively enriched genes in 9- vs 4-week male Znrf3 cKO mice. Data is representative of 4 biological replicates per group and, statistical analysis in IPA was performed using a right-tailed fishers exact test, p < 0.05.