Table 2.

Clinical Trials Using Oncolytic Viruses in Pediatric Brain Tumors

Oncolytic virus	Name	Tumor	NCT number	Phase	Additional therapies on study	No of patients, route (virus)	Status
Herpes simplex virus	HSV1716	Refractory or recurrent pHGG	NCT02031965	Phase I		2, intratumoral	Terminated prematurely
	G207	Recurrent pHGG	NCT02457845	Phase I	Radiation	12, intratumoral	Completed
		Recurrent pHGG	NCT04482933	Phase II	Radiation	40, intratumoral	Not yet recruiting
		Recurrent or refractory cerebellar brain tumors	NCT03911388	Phase I	Radiation	15, intratumoral	Active, recruiting
Adenovirus	Delta-24-RGD	DIPG	NCT03178032	Phase I	Radiation	12, intratumoral	Completed
Poliovirus	PVSRIPO	Grade III or IV malignant glioma	NCT03043391	Phase Ib		8, Intratumoral (CED)	Completed
Measles virus	MV-NIS	Local and disseminated Recurrent Medulloblastoma AT/RT	NCT02962167	Phase I		46, Intratumoral or in the subarachnoid space	Completed (not posted)
Reovirus	Reolysin	Refractory or recurrent pHGG	NCT02444546	Phase I	Sargramostim (GM-CSF)	6, intravenous	Completed