Table 3.

Other effects of PBM therapy in the included studies.

Study	Effects of PBM in EAE-induced mice
Goncalves et al. (27)	Significantly reduced NO levels in spinal cord and spleen No change in lipid peroxidation Significantly reduced infiltration of mononuclear cells into CNS Significantly reduced CNS demyelination
Muili et al. (28)	Significantly reduced proinflammatory cytokines IFN-γ and TNF-α Significantly increased anti-inflammatory cytokines IL-4 and IL-10
Muili et al. (29)	Significantly increased Bcl-2and Bax gene expression during peak disease and 2 days after 2nd treatment Significantly decreased TUNEL+ cells 2 days post disease onset, during peak disease and 2 days after 2nd treatment

NO, nitric oxide; IFN-γ, interferon-γ; TNF-α, tumor necrosis factor-α; IL-4, interleukin-4.