Fig. 10.

Molecular markers of myocardial inflammation, oxidative stress, apoptosis and dysfunction in the left ventricle after doxorubicin (DOXO) treatment (cumulative dose 10 mg/kg BW; one injection per week for five consecutive weeks) measured two and five weeks after the last DOXO injection in Ren-2 transgenic hypertensive rats (TGR) in comparison to the control TGR (placebo-treated) groups. The gene expression was determined by qRT-PCR, the data were normalized on TBP (TATA-binding protein) as a reference gene and shown relative to the control group (control TGR 2 weeks). A Interleukin 6 (IL6); (B) interleukin 1b (IL-1b); (C) superoxide dismutase 2 (SOD2); (D) the ratio of pro-apoptotic Bcl2 associated X (BAX) and anti-apoptotic Bcl2; (E) cyclin dependent kinase inhibitor 1 A (CDKN1A, p21); (F) atrial natriuretic peptide (ANP); P > 0.05 (NS); *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001 by one-way ANOVA with Tukey’s multiple comparisons test