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Pathophysiology of cystic fibrosis liver disease compared to other cirrhotic liver diseases. Portal hypertension occurs early due to obliterative portal venopathy and nodular regenerative hyperplasia. Cirrhosis develops late as a result of portal-based inflammation and fibrosis. CF, cystic fibrosis; AIH, autoimmune hepatitis; PBC, primary biliary cirrhosis; MASLD, metabolic associated steatotic liver disease.
