Table 2.

Univariate and Multivariate Cox Regression Analyses

	Dependent: Surv(time, status == 1)	all	HR (univariable)	HR (multivariable)	HR (final)
Age	Mean ± SD	51.0 ± 17.9	1.03 (1.02-1.04, p<.001)	1.04 (1.02-1.05, p<.001)	1.03 (1.02-1.04, p<.001)
Sex	Male	145 (46.3%)
	Female	168 (53.7%)	0.69 (0.49-0.95, p=.025)	0.68 (0.49-0.95, p=.024)	0.67 (0.48-0.93, p=.017)
Year of diagnosis	before and in 2010	143 (45.7%)
	after 2010	170 (54.3%)	0.68 (0.48-0.96, p=.027)	0.59 (0.41-0.86, p=.006)	0.53 (0.37-0.75, p<.001)
Race	White	253 (80.8%)
	others	60 (19.2%)	1.12 (0.75-1.69, p=.576)
Combined Summary Stage	Localized	89 (28.4%)
	Regional	46 (14.7%)	1.31 (0.72-2.37, p=.374)	1.39 (0.75-2.57, p=.293)
	Distant	108 (34.5%)	1.86 (1.16-2.96, p=.010)	1.51 (0.90-2.54, p=.116)
	Unknown/unstaged	70 (22.4%)	2.09 (1.28-3.40, p=.003)	1.88 (1.08-3.30, p=.026)
Surg Prim Site	no surgery or unknown	229 (73.2%)
	Wedge or segmental resection or Lobectomy	58 (18.5%)	0.41 (0.24-0.69, p<.001)	0.54 (0.31-0.96, p=.036)	0.43 (0.25-0.73, p=.002)
	Hepatectomy and or transplant	26 (8.3%)	0.26 (0.11-0.64, p=.003)	0.29 (0.12-0.73, p=.009)	0.27 (0.11-0.66, p=.004)
Radiation recode	None or Unknown	301 (96.2%)
	radiation performed	12 (3.8%)	1.85 (0.90-3.77, p=.092)
Chemotherapy recode	No or Unknown	226 (72.2%)
	Yes	87 (27.8%)	1.53 (1.08-2.17, p=.017)	2.00 (1.34-2.99, p=.001)	1.89 (1.32-2.72, p=.001)
Systemic Sur Seq	no Systemic therapy after and before surgery	294 (93.9%)
	Systemic therapy after or before surgery	19 (6.1%)	0.94 (0.48-1.85, p=.857)
Sequence number	One primary only	254 (81.2%)
	Over one	59 (18.8%)	1.40 (0.95-2.06, p=.091)
Median_household_income_inflation_adj_to_2021	below $70000	151 (48.2%)
	more than $70000	162 (51.8%)	0.68 (0.49-0.95, p=.023)	0.56 (0.40-0.79, p=.001)	0.57 (0.41-0.80, p=.001)
Rural Urban Continuum Code	Metropolitan (1 million+)	218 (69.6%)
	Other metropolitan or non-metropolitan	95 (30.4%)	1.37 (0.97-1.93, p=.070)

n=313, events=143, Likelihood ratio test=95.49 on 10 df(p<.001).