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. 2024 Nov 4;10:118. doi: 10.1038/s41522-024-00592-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — A Fasting serum histidine levels increased in the type 2 diabetes group after oral histidine supplementation. B Fasting Imidazole propionate levels increased in T2D and controls after two weeks and further increased after antibiotics use. Also, after the recovery period ImP levels were still higher compared to baseline (C) Fasting Urocanate level increased after antibiotics use in both groups but not at other visits compared to baseline. Paired Wilcox test FDR corrected. Control n = 19, Type 2 Diabetes n = 20.