Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Nov 4;15:9520. doi: 10.1038/s41467-024-51719-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a Heatmap showing immune checkpoint molecule expression in the sigmoid colon of healthy patients (HC) (n = 6) and patients with ulcerative colitis (n = 15). b Representative flow plots and (c) summary statistics showing the percentage of different ILC subsets (ILC1s, NCR⁺ ILC3s and NCR^- ILC3s) from patients with IBD (n = 5) and healthy controls (n = 5) that were positive for CTLA-4 after treatment with PMA, ionomycin and monensin for 3 h. *** P = 0.0002 2-way ANOVA with Šídák’s multiple comparisons Test. Lineage⁺ IL-7R⁺ shown as a positive control for CTLA-4 staining on bulk T cells. d Dot plot showing the CTLA-4 gMFI in different ILC subsets (ILC1, NCR⁺ ILC3 and NCR^- ILC3) in patients with IBD (n = 5) compared with healthy controls (n = 5) * P = 0.0423 ** P = 0.0036 2-way ANOVA with Šídák’s multiple comparisons Test. All experimental n in Fig. 5 are biological independent human samples.