Fig. 5.

Effect of DSW treatment on the locomotor function of young and aged mice. Each mouse was placed in a respiratory quotient measuring device, and total locomotor function was measured for 24 h. The total locomotor function of each mouse was determined by the total number of crossings over 24 h captured by a reticulated laser in a sealed chamber (A). Locomotor functions of mice were segregated according to day and night (B). Locomotor functions of individual mice are shown (C). The groups consisted of Young (n = 8), Young + DSW (n = 8), Aged (n = 6), and Aged + DSW (n = 6). The data are shown as means ± SE. Data were analyzed using a one-way analysis of variance followed by a Tukey-Kramer test (A, B). ∗p < 0.05. ∗∗p < 0.01. ∗∗∗∗p < 0.0001.