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. 2024 Sep 13;43(21):5141–5168. doi: 10.1038/s44318-024-00227-w

Figure 7. Histone homeostasis in different nutrient environments.

Figure 7

(A) While cells maintain constant amounts of histone proteins across changing environments, the histone mRNA expression is increased in nutrient-rich conditions. (B, C) Decoupling of protein and mRNA abundance is achieved through nutrient-dependent translation, allowing cells to balance the need for rapid histone production in rich growth media (B) with the tight regulation required to prevent histone overexpression in poor growth media (C).