Table 1. Two-step process and examples of investigational questions for applying the TREM classification.

Step	Examples of investigational questions to ascertain whether error was technology-related and the underlying mechanism
Review of errors in the CPOE	Was the order based on a prebuilt order sentence/template or order set? How was the final dose calculated? Which weight was used in the dose calculator? Were the medication orders before or after the order being investigated placed by the same prescriber? Were there discharge prescriptions generated on the day of the error? Was medication reconciliation conducted on the day of the error? Was there documentation of the prescriber’s intention?
Simulate the errors in the test environment	Is there an error in the order sentence or template? What are the drop-down menu options (eg, order sentences) in close proximity to the order component selected? What is the default in an order when no selection is made or when the prescriber hits the ‘enter’ key? Is there automation during the ordering process that may have contributed to the error? What actions were taken by the prescriber to generate the order?

CPOEcomputerised provider order entryTREMTechnology-Related Error Mechanism