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DNA damage induction and subsequent activation of the inflammasome. A, Neutral thyrotropin receptor antibodies (N-TSHR-mAbs) induced DNA damage along with NLRP3, AIM-2, and interleukin (IL)-1β. B, The antibody also induced caspase 1, ASC, NFκB, and TXNIP. C(a-g), Immunocytochemistry also revealed similar effects including DNA damage protein (8-OHDG), NLRP3, AIM-2, Casp1, Asc, and TXNIP. Red bar = 100 μm; *P less than .05.
