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. 2024 Oct 18;10(20):e39530. doi: 10.1016/j.heliyon.2024.e39530

Table 2.

Risk factors for recurrence in all patients.

Odds ratios 95%CI p-value
Age (≥65 years) 1.322 0.714–2.446 0.374
Male 1.378 0.717–2.649 0.336
APR, TP 3.073 1.479–6.384 0.003
LAP 0.560 0.280–1.120 0.101
Obstraction 3.078 0.932–10.165 0.065
T4 4.859 0.902–26.174 0.066
lymphatic invasion 2.080 1.055–4.101 0.034
vascular invasion 2.702 1.300–5.615 0.008
Poorly tumor differentiation 1.212 0.521–2.821 0.656
number of lymph node resection (<12) 2.081 1.076–4.025 0.029
CEA (>5 ng/mL) 0.991 0.416–2.357 0.983
Neoadjuvant therapy
 CRT/none 2.168 0.911–5.160 0.080
 CRT/CT 0.451 0.049–4.108 0.480
 CRT/RT 1.248 0.098–15.867 0.864
 CT/none 4.811 0.536–43.219 0.161
 CT/RT 2.770 0.104–73.469 0.542
 RT/none 1.737 0.148–20.338 0.660
Adjuvant therapy
 Ox/Non-Ox 1.932 0.318–11.726 0.474
 Ox/nonCT 2.011 0.366–11.040 0.421
 Non-Ox/nonCT 1.041 0.495–2.190 0.916
Odds ratios for recurrence were calculated using regression analysis. Values in parentheses are 95 % confidence intervals. APR, abdominoperineal resection; TP, total pelvic exenteration; LAP, laparoscopic surgery; CEA, carcinoembryonic antigen; CRT, chemoradiotyherapy; CT, chemotherapy; RT, radiotherapy; none, no neoadjuvant therapy; Ox, oxaliplatin-based chemothetapy; Non-Ox, nonoxaliplatin-based chemotherapy; nonCT, no chemotherapy.