Figure 5.

In vivo efficacy and biocompatibility of antioxidant delivery materials

(A) Total antioxidant capacity of Ti₂C. The therapeutic effect of Ti₂C@BSA-ISO in vitro.

(B) Cell survival of primary hippocampal neurons at 0 h, 24 h, and 48 h in different treatment groups. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.

(C) Representative images of TTC-stained coronal brain sections of rats after MCAO. Reproduced with permission from ref.⁴⁰ Copyright 2024 Mater Chem.

(D) Quantification of the proportion of GFAP-positive and IBA-1-positive regions (n = 9 sections).

(E) Quantification of fluorescence intensity in the brain at different time points after intracerebral injection of ICG@pDA-MNOF.

(F) Representative fluorescence images of mice at different time points after intracerebral injection of ICG@pDA-MNOF. Reproduced with permission from ref.⁴³ Copyright 2023 Advanced Science.