Heat map of the antibacterial and antifungal activity profile (in μg mL−1) of chromene diones 11f, 17a,d,f, 18a,d,f and 19f against S. aureus NCTC 6571, S. aureus MRSA ATCC 43300, B. subtilis NCTC 5398, E. faecalis ATCC 29212, L. monocytogenes NCTC 1194, K. pneumoniae ATCC BAA 2146, A. baumannii ATCC 19606, C. auris ATCC 21092 and C. albicans ATCC 10231 compared to toxicity against MRC5 human fibroblast cells. The activity profile of myxocoumarin A (4) is given for comparisona.
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NCTC = National Collection of Type Cultures (NCTC, Culture Collection of Public Health, Salisbury, UK). ATCC = American Type Culture Collection (Manassas, Virginia, USA). Green color indicates biological activity (darker green equals higher activity), orange color toxicity (darker orange equals higher toxicity).