Figure 2.

KINOMEscan trees for selected compounds. Kinome selectivity of tool compounds is measured against >400 human kinases in the scanMAX KINOMEscan^® panel. Compounds were tested at 3 μM final concentration. Circles indicate the major kinase hits and their size is inversely proportional to estimated binding affinity. The enzyme inhibition IC₅₀ values for selected compounds against STK17A and STK17B measured at 1 mM ATP are also shown. Kinome illustration was reproduced courtesy of Cell Signaling Technology, Inc. (www.cellsignal.com) (CSTI). The foregoing website is maintained by CSTI and Blueprint Medicines Corporation is not responsible for its content.