Table 2. List of the Gene Sets That Are Overrepresented in the E2 Treated MCF7 Cells Compared to the Vehicle-Treated Control Cells^a.

	collection: Hallmark		collection: PID pathway
cellular fractions	enriched gene set	FDR	enriched gene set	FDR
cytosolic	estrogen response late	0.099	PID_PDGFRB pathway	0.164
			PID_VEGFR1/2 pathway	0.222
nuclear	estrogen response late	0.001
	E2F targets	0.115
	Heme metabolism	0.121
	Complement	0.162
membrane/organelle	E2F targets	0.078	PID_REG_GR pathway	0.001
	G2/M checkpoint	0.096	PID_LKB1_pathway	0.007
	PI3K AKT mTOR signaling	0.145	PID_NFAT_3 pathway	0.016
			PID_mTOR_4 pathway	0.015
			PID_Hedgehog_Gli pathway	0.015
			PID_beta_Catenin_Nuc pathway	0.014
			PID_Telomerase pathway	0.012
			PID_PDGFRB pathway	0.018
			PID_FOXO pathway	0.037
			PID_ERBB1_Downstream pathway	0.040
			PID_VEGFR1/2 pathway	0.053
			PID_MET pathway	0.060
			PID_A6B1_A6B4_Integrin pathway	0.056
			PID_ILK pathway	0.212
			PID_TRKR pathway	0.248
			PID_Thrombin_Par1 pathway	0.240
			PID_Myc_Activ pathway	0.233

^aOnly the gene sets with FDR less than 0.25 are listed.