Table 3. Functional Annotation Analysis by DAVID of the Proteins Whose Expression Was Significantly Upregulated by E2: with GOTERM_BP_DIRECT and GOTERM_MF_DIRECTa.
| category | term | count | UniProt ID | p value | fold enrichment |
|---|---|---|---|---|---|
| cluster 1 | enrichment score: 4.78 | ||||
| GOTERM_MF_DIRECT | GO:0031267 ∼ small GTPase binding | 13 | Q14974, O00429, O14980, Q07960, Q8TEX9, Q9Y3P9, Q96P70, O95373, O60610, Q92973, Q13492, O14787, P55060 | 3.76 × 10–07 | 6.9 |
| GOTERM_MF_DIRECT | GO:0061608 ∼ nuclear import signal receptor activity | 5 | Q14974, Q92973, O14787, Q8TEX9, Q96P70 | 7.09 × 10–06 | 38.8 |
| GOTERM_BP_DIRECT | GO:0006606 ∼ protein import into nucleus | 7 | Q14974, Q92973, O14787, P55060, Q8TEX9, Q96P70, O95373 | 4.17 × 10–05 | 11.0 |
| GOTERM_MF_DIRECT | GO:0008139 ∼ nuclear localization sequence binding | 4 | Q14974, Q92973, O14787, Q8TEX9 | 6.65 × 10–04 | 23.0 |
| cluster 2 | enrichment score: 3.66 | ||||
| GOTERM_BP_DIRECT | GO:0006413 ∼ translational initiation | 7 | O15371, Q04637, Q99613, O75821, O00571, Q15056, P60842 | 9.59 × 10–07 | 20.9 |
| GOTERM_MF_DIRECT | GO:0003743 ∼ translation initiation factor activity | 6 | O15371, Q04637, Q99613, O75821, Q15056, P60842 | 5.52 × 10–05 | 14.6 |
| GOTERM_BP_DIRECT | GO:0001732 ∼ formation of cytoplasmic translation initiation complex | 3 | O15371, Q99613, O75821 | 0.0046 | 29.0 |
| GOTERM_MF_DIRECT | GO:0008135 ∼ translation factor activity, RNA binding | 3 | Q04637, Q15056, P60842 | 0.0094 | 20.2 |
| cluster 3 | enrichment score: 2.69 | ||||
| GOTERM_BP_DIRECT | GO:1900152 ∼ negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 3 | P67809, P11940, O60506 | 0.0013 | 54.8 |
| GOTERM_BP_DIRECT | GO:0070934 ∼ CRD-mediated mRNA stabilization | 3 | P67809, P11940, O60506 | 0.0019 | 44.9 |
| GOTERM_BP_DIRECT | GO:2000767 ∼ positive regulation of cytoplasmic translation | 3 | P67809, P11940, O60506 | 0.0036 | 32.9 |
| cluster 4 | enrichment score: 2.67 | ||||
| GOTERM_BP_DIRECT | GO:0061077 ∼ chaperone-mediated protein folding | 6 | P50990, O75190, P78371, P49368, P04792, Q02790 | 3.57 × 10–06 | 25.3 |
| GOTERM_MF_DIRECT | GO:0051082 ∼ unfolded protein binding | 7 | P50990, O00170, O75190, Q8N163, P78371, P49368, P04792 | 1.88 × 10–04 | 8.4 |
| GOTERM_MF_DIRECT | GO:0044183 ∼ protein binding involved in protein folding | 5 | P50990, O75190, P78371, P49368, P04792 | 3.14 × 10–04 | 15.2 |
| GOTERM_BP_DIRECT | GO:0032212 ∼ positive regulation of telomere maintenance via telomerase | 4 | P50990, P78371, P49368, P09651 | 0.0011 | 19.4 |
| GOTERM_BP_DIRECT | GO:1904851 ∼ positive regulation of establishment of protein localization to telomere | 3 | P50990, P78371, P49368 | 0.0016 | 49.4 |
| GOTERM_BP_DIRECT | GO:1904871 ∼ positive regulation of protein localization to Cajal body | 3 | P50990, P78371, P49368 | 0.0019 | 44.9 |
| GOTERM_BP_DIRECT | GO:1904874 ∼ positive regulation of telomerase RNA localization to Cajal body | 3 | P50990, P78371, P49368 | 0.0036 | 32.9 |
| GOTERM_BP_DIRECT | GO:0050821 ∼ protein stabilization | 6 | P50990, P78371, P46379, P49368, P83436, O60716 | 0.0122 | 4.3 |
| GOTERM_MF_DIRECT | GO:0016887 ∼ ATPase activity | 8 | P50990, P78371, P33993, O00571, P49368, P49736, O00148, P60842 | 0.0181 | 3.0 |
| GOTERM_BP_DIRECT | GO:0007339 ∼ binding of sperm to zona pellucida | 3 | P50990, P78371, P49368 | 0.0242 | 12.3 |
| GOTERM_BP_DIRECT | GO:0006457 ∼ protein folding | 5 | P50990, O75190, P78371, P49368, Q02790 | 0.0253 | 4.5 |
| GOTERM_BP_DIRECT | GO:1901998 ∼ toxin transport | 3 | P50990, P78371, P49368 | 0.0265 | 11.8 |
| cluster 5 | enrichment score: 1.75 | ||||
| GOTERM_BP_DIRECT | GO:0001836 ∼ release of cytochrome c from mitochondria | 3 | O00429, Q07812, P55957 | 0.0084 | 21.5 |
| GOTERM_BP_DIRECT | GO:0090200 ∼ positive regulation of release of cytochrome c from mitochondria | 3 | O00429, Q07812, P55957 | 0.0114 | 18.3 |
| GOTERM_BP_DIRECT | GO:2001244 ∼ positive regulation of intrinsic apoptotic signaling pathway | 3 | O00429, Q07812, P55957 | 0.0209 | 13.3 |
| GOTERM_BP_DIRECT | GO:0043065 ∼ positive regulation of apoptotic process | 6 | O00429, P50570, Q8N163, Q07812, O00571, P55957 | 0.0480 | 3.0 |
| cluster 6 | enrichment score: 1.58 | ||||
| GOTERM_BP_DIRECT | GO:0006334 ∼ nucleosome assembly | 5 | P49321, Q01105, P16403, P49736, P16402 | 0.0144 | 5.4 |
| GOTERM_MF_DIRECT | GO:0042393 ∼ histone binding | 5 | P49321, Q01105, Q96P70, P49736, O95373 | 0.0342 | 4.1 |
| GOTERM_BP_DIRECT | GO:0006260 ∼ DNA replication | 4 | P49321, Q01105, P33993, P49736 | 0.0368 | 5.4 |
| cluster 7 | enrichment score: 1.19 | ||||
| GOTERM_BP_DIRECT | GO:0071902 ∼ positive regulation of protein serine/threonine kinase activity | 3 | P36507, O00571, Q02750 | 0.0265 | 11.8 |
a
Only the categories and terms with p < 0.05 are listed.