Table 4. Functional Annotation Analysis by DAVID Software of the Proteins Whose Expression Was Significantly Upregulated by E2: with UP_SEQ_FEATUREa.
| category | term | count | UniProt ID | p value | fold enrichment |
|---|---|---|---|---|---|
| cluster 1 | enrichment score: 6.37 | ||||
| UP_SEQ_FEATURE | DOMAIN:Importin N-terminal | 8 | Q14974, O14980, Q92973, O14787, P55060, Q8TEX9, Q96P70, O95373 | 2.13 × 10–12 | 84.9 |
| UP_SEQ_FEATURE | REPEAT:HEAT 4 | 9 | Q14974, Q6AI08, O14980, Q92973, P53618, Q86VP6, P30153, O14787, Q8TEX9 | 4.68 × 10–10 | 30.6 |
| UP_SEQ_FEATURE | REPEAT:HEAT 3 | 9 | Q14974, Q6AI08, O14980, Q92973, P53618, Q86VP6, P30153, O14787, Q8TEX9 | 1.39 × 10–09 | 26.8 |
| UP_SEQ_FEATURE | REPEAT:HEAT 6 | 8 | Q14974, O14980, Q92973, P53618, Q86VP6, P30153, O14787, Q8TEX9 | 1.73 × 10–09 | 36.7 |
| UP_SEQ_FEATURE | REPEAT:HEAT 1 | 9 | Q14974, Q6AI08, O14980, Q92973, P53618, Q86VP6, P30153, O14787, Q8TEX9 | 4.63 × 10–09 | 23.2 |
| UP_SEQ_FEATURE | REPEAT:HEAT 2 | 9 | Q14974, Q6AI08, O14980, Q92973, P53618, Q86VP6, P30153, O14787, Q8TEX9 | 4.63 × 10–09 | 23.2 |
| UP_SEQ_FEATURE | REPEAT:HEAT 5 | 8 | Q14974, O14980, Q92973, P53618, Q86VP6, P30153, O14787, Q8TEX9 | 5.27 × 10–09 | 31.6 |
| UP_SEQ_FEATURE | REPEAT:HEAT 10 | 6 | Q14974, O14980, Q92973, Q86VP6, P30153, O14787 | 2.43 × 10–07 | 42.4 |
| UP_SEQ_FEATURE | REPEAT:HEAT 9 | 6 | Q14974, O14980, Q92973, Q86VP6, P30153, O14787 | 3.03 × 10–07 | 40.8 |
| UP_SEQ_FEATURE | REPEAT:HEAT 8 | 6 | Q14974, O14980, Q92973, Q86VP6, P30153, O14787 | 5.52 × 10–07 | 36.4 |
| UP_SEQ_FEATURE | REPEAT:HEAT 7 | 6 | Q14974, O14980, Q92973, Q86VP6, P30153, O14787 | 1.11 × 10–06 | 31.8 |
| UP_SEQ_FEATURE | REPEAT:HEAT 15 | 5 | Q14974, Q92973, Q86VP6, P30153, O14787 | 1.44 × 10–06 | 56.6 |
| UP_SEQ_FEATURE | REPEAT:HEAT 14 | 5 | Q14974, Q92973, Q86VP6, P30153, O14787 | 2.48 × 10–06 | 49.9 |
| UP_SEQ_FEATURE | REPEAT:HEAT 12 | 5 | Q14974, Q92973, Q86VP6, P30153, O14787 | 3.18 × 10–06 | 47.2 |
| UP_SEQ_FEATURE | REPEAT:HEAT 13 | 5 | Q14974, Q92973, Q86VP6, P30153, O14787 | 3.18 × 10–06 | 47.2 |
| UP_SEQ_FEATURE | REPEAT:HEAT 11 | 5 | Q14974, Q92973, Q86VP6, P30153, O14787 | 4.99 × 10–06 | 42.4 |
| UP_SEQ_FEATURE | REPEAT:HEAT 17 | 4 | Q14974, Q92973, Q86VP6, O14787 | 2.26 × 10–05 | 67.9 |
| UP_SEQ_FEATURE | REPEAT:HEAT 18 | 4 | Q14974, Q92973, Q86VP6, O14787 | 2.26 × 10–05 | 67.9 |
| UP_SEQ_FEATURE | REPEAT:HEAT 19 | 4 | Q14974, Q92973, Q86VP6, O14787 | 2.26 × 10–05 | 67.9 |
| UP_SEQ_FEATURE | REPEAT:HEAT 16 | 4 | Q14974, Q92973, Q86VP6, O14787 | 3.10 × 10–05 | 61.7 |
| UP_SEQ_FEATURE | REPEAT:HEAT 20 | 3 | Q92973, Q86VP6, O14787 | 0.0012 | 56.6 |
| UP_SEQ_FEATURE | REPEAT:HEAT | 3 | Q14974, P30153, Q8TEX9 | 0.0072 | 23.1 |
| cluster 2 | enrichment score: 5.97 | ||||
| UP_SEQ_FEATURE | DOMAIN:KH 1 | 6 | Q96AE4, Q96I24, P61978, Q15366, P51114, Q15365 | 2.43 × 10–07 | 42.4 |
| UP_SEQ_FEATURE | DOMAIN:KH 2 | 6 | Q96AE4, Q96I24, P61978, Q15366, P51114, Q15365 | 2.43 × 10–07 | 42.4 |
| UP_SEQ_FEATURE | DOMAIN:KH 3 | 5 | Q96AE4, Q96I24, P61978, Q15366, Q15365 | 1.06 × 10–06 | 60.6 |
| UP_SEQ_FEATURE | DOMAIN:K Homology | 5 | Q96AE4, Q96I24, P61978, Q15366, Q15365 | 2.03 × 10–05 | 30.3 |
| cluster 3 | enrichment score: 4.87 | ||||
| UP_SEQ_FEATURE | DOMAIN:RRM | 11 | P52597, P31942, Q13148, O75821, P98179, P11940, Q8N684, P09651, O60506, P26599, Q15056 | 1.43 × 10–06 | 7.8 |
| UP_SEQ_FEATURE | DOMAIN:RRM 1 | 8 | P52597, P31942, Q13148, Q13151, P11940, P09651, O60506, P26599 | 2.76 × 10–06 | 12.9 |
| UP_SEQ_FEATURE | DOMAIN:RRM 2 | 8 | P52597, P31942, Q13148, Q13151, P11940, P09651, O60506, P26599 | 2.76 × 10–06 | 12.9 |
| UP_SEQ_FEATURE | DOMAIN:RRM 3 | 4 | P52597, P11940, O60506, P26599 | 0.0031 | 13.6 |
| cluster 4 | enrichment score: 1.29 | ||||
| UP_SEQ_FEATURE | DOMAIN:DEAD-box RNA helicase Q | 3 | O00571, O00148, P60842 | 0.0132 | 17.0 |
| UP_SEQ_FEATURE | MOTIF:Q motif | 3 | O00571, O00148, P60842 | 0.0228 | 12.7 |
a
Only the categories and terms with p < 0.05 are listed.