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. 2024 Oct 9;23(11):5048–5063. doi: 10.1021/acs.jproteome.4c00471

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© 2024 The Authors. Published by American Chemical Society

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(A) Unique proteins identified in each fraction, here stratified for gradient length (100, 60, 40 SPD) while comparing DDA vs DIA, with and without the gas-phase spectral library using the sample pool. (B) The same, but for unique peptides. (C) Number of unique proteins identified in this study vs previous literature. (D) The efficiency of quantifying the number of unique proteins, here measured as . (E) The overlap between unique proteins identified in this study and compared to previous studies on CSF from healthy donors. (G) The same, but the CSF study was performed on EV-enriched samples from pediatric patients with a brain tumor.

Inline graphic — (A) Unique proteins identified in each fraction, here stratified for gradient length (100, 60, 40 SPD) while comparing DDA vs DIA, with and without the gas-phase spectral library using the sample pool. (B) The same, but for unique peptides. (C) Number of unique proteins identified in this study vs previous literature. (D) The efficiency of quantifying the number of unique proteins, here measured as . (E) The overlap between unique proteins identified in this study and compared to previous studies on CSF from healthy donors. (G) The same, but the CSF study was performed on EV-enriched samples from pediatric patients with a brain tumor.