Figure 1.

Lessons learned from the Blue Zones, the 6 Lifestyle Medicine Pillars and recent results from the literature support the association between healthy eating, physical activity, avoidance of risky substances, stress management and maintenance of good mental health, restorative sleep and positive family and social connections and wellbeing and longevity. Future studies should assess the combined effects of behavioral and genetic factors on molecular pathways to understand their contribution to longevity.