TABLE 2.

Antibiotic susceptibility: MIC of different antibiotics determined for P. aeruginosa WT and ∆mlaA (N = 3) , ND not determined

	Antibiotics	Generic abbreviation	Target/Process	MICs (µg/mL)
				Wild-type	∆mlaA
Aminoglycosides	Amikacin	AMK	Binding to the aminoacyl site of 16S ribosomal RNA within the 30S ribosomal subunit	8	8
	Gentamicin	GEN		4	4
	Tobramycin	TOB		1	2
	Neomycin	NEO		128	>128
	Neamine	NEA		>512	>512
Amphiphilic aminoglycoside derivative	3’,6-dinonyl neamine	3’,6-diNn	Binding to the LPS & GPL domains	4	4
Polymyxin	Colistin	COL	Binding to the LPS	4	2
Fluoroquinolones	Ciprofloxacin	CIP	Inhibiting DNA gyrase or topoisomerase IV	0.25	0.125
	Levofloxacin	LVX
				1	0.25
	Moxifloxacin	MXF		2	0.5
Carbapenems	Imipenem	IPM	Binding to the penicillin-binding proteins	4	4
	Meropenem	MEM		0.5	1
Cephalosporins	Cefepime	FEP	Inhibiting penicillin-sensitive enzymes (transpeptidases, carboxypeptidases)	2	2
	Ceftazidime	CAZ		1	2
Penicillin	Temocillin	TMO	Inhibiting the transpeptidase that catalyzes the final step in cell wall biosynthesis	>64	>64
Glycopeptide	Vancomycin	VAN	Binding to the acyl-d-alanyl-d-alanine terminus of the growing peptidoglycan	>512	>512
Lipoglycopeptides	Telavancin	TEL	Inserting the lipophilic tail into the bacterial cell membrane causes rapid membrane depolarization and a potassium ion efflux	>512	>512
	Daptomycin	DAP		>512	>512
Rifamycin	Rifampicin	RIF	Inhibiting bacterial DNA-dependent RNA polymerase	16	16
Macrolide	Erythromycin	ERY	Binding to the 23S ribosomal RNA molecule in the 50S subunit of ribosomes	>64	>64
Aminocoumarin	Novobiocin	NVB	Inhibiting GyrB subunit of the bacterial DNA gyrase	>64	>64
Oxazolidinone	Linezolid	LZD	Binding a site on the bacterial 23S ribosomal RNA of the 50S subunit	0.5	1