TABLE 3.
Competing risk events analysis of recurrent VADI using Fine and Gray’s sub-distribution hazard modela
| Variable | Observed proportion of events | Univariable | Multivariable | ||
|---|---|---|---|---|---|
| Unadjusted SHR (95% CI) | P value | Adjusted SHR (95% CI) | P value | ||
| Chronic suppressive antibiotics | 36% (13/36) vs 70% (28/40) | 0.43 (0.22–0.82) | 0.01 | 0.40 (0.18–0.89) | 0.03 |
| Cardiovascular implantable electronic device | 58% (21/36) vs 50% (20/40) | 1.09 (0.59–2.00) | 0.79 | 1.21 (0.62–2.37) | 0.58 |
| Causative pathogen | |||||
| S. aureus | 50% (24/48) | Reference | Reference | ||
| P. aeruginosa | 80% (12/15) | 2.13 (1.05–4.32) | 0.04 | 1.36 (0.58–3.17) | 0.48 |
| Others | 38% (5/13) | 0.61 (0.25–1.49) | 0.28 | 0.38 (0.13–1.13) | 0.08 |
| Surgical intervention for primary infection | 71% (17/24) vs 46% (24/52) | 1.89 (1.03–3.47) | 0.04 | 2.16 (1.15–4.03) | 0.02 |
| VAD-related infection (compared with VAD-specific) | 46% (6/13) vs 55% (35/63) | 0.78 (0.31–1.96) | 0.60 | 1.07 (0.35–3.34) | 0.90 |
| Age (years) | 40 (41) vs 42 (35) | 0.99 (0.97–1.01) | 0.44 | ||
| BMI (kg/m2) | 21.2 (41) vs 21.5 (34) | 0.96 (0.88–1.05) | 0.40 | ||
| Male | 53% (31/58) vs 55% (10/18) | 0.88 (0.43–1.78) | 0.72 | ||
| Diabetes | 60% (3/5) vs 53% (38/71) | 1.16 (0.40–3.34) | 0.78 | ||
| CRD | 55% (5/9) vs 53% (36/67) | 0.94 (0.36–2.42) | 0.90 | ||
| Previous cardiac surgery | 58% (20/34) vs 50% (21/42) | 1.23 (0.67–2.25) | 0.50 | ||
| Alcohol | 57% (4/7) vs 53% (37/69) | 0.91 (0.35–2.39) | 0.86 | ||
| Smoking | 52% (12/23) vs 54% (29/53) | 0.90 (0.47–1.74) | 0.76 | ||
a
BMI, body mass index; CRD, chronic renal disease.