Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The key step of in vitro selection, in which the deoxyribozyme (lower strand) catalyzes the RNA ligation reaction of Figure 1. The covalent loop marked with an asterisk is present during the selection procedure, but the loop is not required for practical ligation of two RNA substrates. The internal nucleotide marked with an arrow is the branch site for the 6CE8 deoxyribozyme, which is the focus of this report.
