Table 2A-C.
TIBAT measurements following acute systemic administration of the beta-3 receptor agonist (CL 316243) or vehicle in male DIO rats. A, injection day 1 (0.5 mg/kg) and B, injection day 22 (0.5 mg/kg). Data are expressed as mean ± SEM. *P<0.05 vs VEH; †0.05<P<0.1 vs VEH.
| Table 2A. Changes in TIBAT Following Systemic OT +/− CL 316243 | ||||||
|---|---|---|---|---|---|---|
| Treatment in Male DIO Rats (Injection Day 1) | ||||||
| SC | IP | 0 min | 15 min | 30 min | 45 min | 60 min |
| Temp (C°) | Temp (C°) | Temp (C°) | Temp (C°) | Temp (C°) | ||
| VEH | VEH | 37.1±.0.4 | 37.3±.0.8 | 37.7±.0.3 | 37.5±.0.3 | 37.4±.0.3 |
| VEH | CL 316243 | 36.8±.0.2 | 38.3±.0.2† | 38.6±.0.2* | 38.5±.0.2* | 38.5±.0.2* |
| OT | VEH | 36.6±.0.3 | 37.7±.0.2 | 37.3±.0.2 | 37.3±.0.2 | 37.0±.0.2 |
| OT | CL 316243 | 36.6±.0.2 | 38.2±.0.2† | 38.4±.02* | 38.3±.0.2* | 38.1±.0.1* |
| *P<0.05 vs VEH | ||||||
| N=8–12/group | ||||||
| Table 2B. Changes in TIBAT Following Systemic OT +/− CL 316243 | ||||||
| Treatment in Male DIO Rats (Injection Dav 22) | ||||||
| SC | IP | 0 min | 15 min | 30 min | 45 min | 60 min |
| Temp (C°) | Temp (C°) | Temp (C°) | Temp (C°) | Temp (C°) | ||
| VEH | VEH | 36.5±.0.3 | 37.7±.0.2 | 37.1±.0.3 | 37.0±.0.2 | 37.1±.0.3 |
| VEH | CL 316243 | 36.8±.0.2 | 38.5±.0.2* | 38.3±.0.2* | 38.2±.0.2* | 38.1±.0.2* |
| OT | VEH | 36.2±.0.2 | 37.4±.0.1 | 37.0±.0.2 | 36.9±.0.2 | 37.0±.0.2 |
| OT | CL 316243 | 36.4±.0.1 | 38.1±.0.2† | 37.9±.0.1* | 37.7±.0.2* | 37.7±.0.2† |
| *P<0.05 vs VEH | ||||||
| N=10–12/group | ||||||