Table 3.
Plasma measurements following 4V infusions of OT (16 nmol/day), CL 316243 (0.5 mg/kg) or OT (16 nmol/day) + CL 316243 (0.5 mg/kg) in DIO rats. Data are expressed as mean ± SEM. Different letters denote significant differences between treatments (P<0.05).
| SC | VEH/VEH | OTA/VEH | VEH/CL 316243 | OT/CL 316243 |
|---|---|---|---|---|
| Leptin (ng/mL) | 47.2 ± 6.0a | 45.9 ± 4.9a | 25.8 ± 3.4b | 22.0 ± 2.4b |
| Insulin (ng/mL) | 10.9 ± 2.3ac | 11.7 ± 1.5a | 6.6 ± 1.2bc | 4.3 ± 0.8b |
| FGF-21 (pg/mL) | 187.3 ± 22.5a | 163.9 ± 9.1a | 87.7 ± 8.0b | 101.5 ± 11.6c |
| Irisin (μg/mL) | 3.9 ± 0.3a | 4.5 ± 0.6a | 4.6 ± 0.4a | 4.4 ± 0.4a |
| Adiponectin (μg/mL) | 6.4 ± 0.6ac | 6.3 ± 0.6ac | 7.3 ± 0.6bc | 8.7 ± 0.5b |
| Blood Glucose (mg/dL) | 179.3 ± 24.5a | 174.9 ± 9.3a | 150 ± 3.7ab | 138 ± 4.5b |
| Glucose (mg/dL) | 206.2 ± 10.7a | 213.1 ± 12.2a | 173.2 ± 7.7b | 180.9 ± 6.3b |
| Triglycerides (mg/dL) | 81.5 ± 13.7ab | 97.5 ± 33.1a | 39.8 ± 3.9b | 47.8 ± 3.3ab |
| FFA (mEq/L) | 0.5 ± 0.1a | 0.5 ± 0.1a | 0.2 ± 0.02b | 0.3 ± 0.03ab |
| Total Cholesterol (mg/dL) | 100.0 ± 6.0a | 108.1 ± 9.7a | 94.5 ± 5.1a | 107.0 ± 10.2a |
Different letters denote significant differences between treatments
Shared letters are not significantly different from one another
N=10–12/group