Table 3B.

Changes in EWAT mRNA Expression Following SC OT and CL 316243 Treatment in Male DIO Rats

SC Treatment	VEH/VEH	OT/VEH	VEH/CL 316243	OT/CL 316243
EWAT
Adrb1	1.0 ± 0.2	1.0 ± 0.2	1.2 ± 0.2	1.0 ± 0.2
Adrb3	1.0 ± 0.2	1.1 ± 0.2	1.3 ± 0.1	1.8 ± 0.2*
Ucp1	1.0 ± 0.3	0.7 ± 0.2	38.8 ± 12.2*	60.5 ± 15.8*
Cidea	1.0 ± 0.2	0.9 ± 0.1	1.0± 0.2	1.3 ± 0.2
Dio2	1.0 ± 0.5	1.0 ± 0.4	2.0 ± 0.6	9.7 ± 3.8*
Gpr120	1.0 ± 0.2	1.0 ± 0.2	1.3 ± 0.2	1.2 ± 0.2
Prdm16	1.0 ± 0.1	1.0 ± 0.1	1.3 ± 0.2	1.3 ± 0.2
Ppargc1a	1.0 ± 0.3	0.7 ± 0.2	1.6 ± 0.2	13.7 ± 7.3*

EWAT was collected in 6-h fasted rats at 2-h post-injection of vehicle or CL 316243 (0.5 mg/kg)

^*P <0.05 vs vehicle

N=8–11/group