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Changes in IWAT mRNA Expression Following SC OT and CL 316243 Treatment in Male DIO Rats
| SC Treatment | VEH/VEH | OT/VEH | VEH/CL 316243 | OT/CL 316243 |
|---|---|---|---|---|
|
| ||||
|
IWAT
|
||||
| Adrb3 | 1.0 ± 0.4 | 1.1 ± 0.6 | 1.0 ± 0.3 | 0.5 ± 0.2 |
| Ucp1 | 1.0 ± 0.4 | 0.3 ± 0.1 | 0.5 ± 0.2 | 1.7 ± 0.8 |
| Dio2 | 1.0 ± 0.3 | 1.0 ± 0.2 | 0.6 ± 0.2 | 0.9 ± 0.3 |
| Ppargc1a | 1.0 ± 0.7 | 0.5 ± 0.4 | 1.5 ± 1.0 | 0.04 ± 0.02 |
IWAT was collected in 6-h fasted rats at 2-h post-injection of vehicle or CL 316243 (0.5 mg/kg)
P <0.05 vs vehicle
N=9–12/group
