TABLE 3.
Distribution of different coresistances within the respective resistance genotypes and serotypes among 60 macrolide-resistant S. pneumoniae isolates
| Antibiotica | No. of strains of the following type resistant to the indicated antibiotic
|
||||||
|---|---|---|---|---|---|---|---|
| Resistance genotype
|
Serotype
|
||||||
| erm(B) | mef(A) | Mutation in 23S rRNAb | 14 | 6B | 19F | Other | |
| No coresistance | 1 | 28 | 1 | 24 | 4 | 2b | |
| CHL | 1 | 1 | |||||
| TET | 4 | 1 | 2 | 3 | |||
| SXT | 2 | 2 | |||||
| SXT, CHL | 1 | 1 | |||||
| TET, CHL | 1 | 1 | |||||
| TET, SXT | 3c | 2 | 1 | 2 | 2c | ||
| PEN, SXT | 1 | 1 | |||||
| PEN, TET | 4 | 2 | 3 | 2 | 1 | ||
| TET, SXT, CHL | 1 | 1 | |||||
| PEN, TET, SXT | 4 | 1 | 2 | 1 | 2 | ||
| PEN, TET, SXT, CHL | 2 | 2 | |||||
| Total (n = 60) | 23 | 36 | 1 | 26 | 16 | 8 | 10 |
a
PEN, penicillin G; TET, tetracycline; SXT, trimethoprim-sulfamethoxazole; CHL, chloramphenicol.
b
Includes a single strain with a weak cMLSB phenotype and no detectable macrolide resistance gene but a mutation in the 23S rRNA gene at position 2058 (A2058G).
c
Including one inducible strain (iMLSB).