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Percentages of isolates exhibiting a given mutation frequency to rifampin resistance among (a) 195 S. pneumoniae isolates from non-CF patients (data are from reference 23) and (b) from 37 S. pneumoniae isolates from CF patients. The dotted lines show mutation frequencies of control strains as follows: for strain R800, normomutable (2.6 × 10−8), and for R310, hypermutable (1.06 × 10−7).
