TABLE 2.
Antimicrobial susceptibilities of S. pneumoniae isolates from CF patients followed at Ramón y Cajal University Hospital in Madrid, Spain
| Antimicrobial agent | MIC (μg/ml)
|
% of isolates
|
||||
|---|---|---|---|---|---|---|
| Range | 50 | 90 | Susceptible | Intermediate | Resistant | |
| Penicillin | ≤0.03-4 | 1 | 2 | 27.0 | 27.0 | 46.0 |
| Ampicillin | ≤0.06-4 | 1 | 4 | —a | — | — |
| Amoxicillin-clavulanate | ≤0.5->4/2 | ≤0.5 | 1/0.5 | 94.0 | 2.0 | 4.0 |
| Cefuroxime | ≤0.12->8 | 2 | 4 | 37.5 | 12.5 | 50.0 |
| Cefotaxime | ≤0.03->4 | 0.5 | 1 | 66.6 | 29.0 | 4.4 |
| Cefepime | ≤0.06->2 | 1 | 2 | 43.8 | 31.2 | 25.0 |
| Meropenem | ≤0.12-1 | 0.5 | 1 | 48.0 | 39.5 | 12.5 |
| Vancomycin | ≤0.25-0.5 | ≤0.25 | 0.5 | 100.0 | 0 | 0 |
| Teicoplanin | ≤0.25 | ≤0.25 | ≤0.25 | 100.0 | 0 | 0 |
| Erythromycin | ≤0.25->1 | >1 | >1 | 58.4 | 0 | 41.6 |
| Clarithromycin | ≤0.25->16 | ≤0.25 | >16 | 62.5 | 2.0 | 35.5 |
| Clindamycin | ≤0.12->1 | ≤0.12 | >1 | 70.9 | 4.1 | 25.0 |
| Tetracycline | ≤0.25->4 | >4 | >4 | 41.7 | 0 | 58.3 |
| Ciprofloxacin | ≤0.06-2 | 1 | 1 | — | — | — |
| Levofloxacin | ≤0.25-2 | 1 | 1 | 100.0 | 0 | 0 |
| SxTb | ≤0.5/9->2/38 | >2/38 | >2/38 | 33.4 | 4.1 | 62.5 |
| Chloramphenicol | ≤2->4 | >4 | >4 | 52.0 | 0 | 48.0 |
| Rifampin | ≤0.5->2 | <0.5 | <0.5 | 98.0 | 0 | 2.0 |
a
—, no NCCLS criteria available.
b
SxT, trimethoprim-sulfametoxazole.