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. Author manuscript; available in PMC: 2024 Nov 5.
Published in final edited form as: Sci Immunol. 2024 Oct 25;9(100):eadp0707. doi: 10.1126/sciimmunol.adp0707

Fig. 1. Biochemical characterization and cryoEM structure of CD45:E3/49K complex.

Fig. 1.

(A) SPR plot of CD45 and E3/49K strain D19a. (B) Example CD69 expression upon pretreatment with E3/49K then stimulated with OKT3 in Jurkat T cells (left) and quantification from replicates (right). (C) Superdex 200 size-exclusion chromatography CD45:E3/49K complex. (D) CryoEM density map of CD45 dimer (red and purple) bound by a single E3/49K (green) resolved to 3.8-Å resolution.