Skip to main content
. Author manuscript; available in PMC: 2024 Nov 5.
Published in final edited form as: Sci Immunol. 2024 Oct 25;9(100):eadp0707. doi: 10.1126/sciimmunol.adp0707

Fig. 4. CD45 dimerization reduces T cell signaling through Lck and Zap70.

Fig. 4.

(A) Detection of specific phosphorylation in Lck and Zap70 in Jurkat cells by protein immunoblot after various treatments. Compound 211 and NQ301 are purchased from different sources with identical chemical formula. Numbers below panels denote quantification of band intensity normalized as: (*) Lck pY394/Lck ratio, (**) Lck pY505/Lck ratio, (***) pZap70/Zap70 ratio. (B) Schematic depiction of CD45-mediated T cell signaling before (left) and after (right) binding of E3/49K binding.