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. Author manuscript; available in PMC: 2024 Nov 5.
Published in final edited form as: Sci Immunol. 2024 Oct 25;9(100):eadp0707. doi: 10.1126/sciimmunol.adp0707

Fig. 5. CD45 distancing tunes T cell signaling.

Fig. 5.

(A) Cartoon representation of E3/49K constructs with extended flexible or rigid linkers. (B) PBMCs were pretreated with E3/49K with different types of linkers then stimulated with OKT3 and assayed for CD69 expression in CD4+ (left) and CD8+ (right) T cells. Data are mean ± s.d. from n = 5 replicates from different donors. Statistical significance is determined by a one-way ANOVA with Fisher’s LSD multiple comparison test (ns > 0.05; *P < 0.05; **P < 0.01, ***P < 0.001; ****P < 0.0001).